Published Studies

	BIOVAXID™		Chronic Sinusitis

Overview Paper- A Paradigm Shift in CRS

Sasama, et al New paradigm for the roles of fungi and eosinophils in chronic rhinosinusitis.
Curr Opin Otolaryngol Head Neck Surg. 2005 Feb;13(1):2-8.

Gosepath, et al. Role of fungus in eosinophilic sinusitis Current Opinion in Otolaryngology & Head and Neck Surgery 2005,
13:9–13

Ponikau J, et al. Striking deposition of toxic eosinophil major basic protein in mucus: Implications for chronic rhinosinusitis. Journal of Allergy and Clinical Immunology, 2005

Definition Papers (new)

Benninger MS et al, 2003, Adult chronic rhinosinusitis: Definitions, diagnosis, epidemiology, and pathophysiology. Otolaryngology, Head and Neck Surgery 129:s1-s32.

Meltzer EO et al, 2004, Rhinosinusitis:Establishing definitions for clinical research and patient care. J Allergy Clinical Immunology 114: s155-s212

Meltzer, EO et al. Rhinosinusitis: Developing guidance for clinical trials
Journal of Allergy and Clinical Immunology, Volume 118, Issue 5, Supplement 1, November 2006, S17-S61

Clinical Trials

Study 1 (Mayo Study):
Intranasal antifungal treatment in 51 patients with chronic rhinosinusitis.
J Allergy Clin Immunol. 2002 Dec;110(6):862-6.

Study 2 (Geneva University Study)
Effect of anti-fungal nasal lavage with amphotericin B on nasal polyposis.
J Laryngol Otol. 2002 Apr;116(4):261-3.

Study 3 (Mayo Study):
Treatment of chronic rhinosinusitis with intranasal amphotericin B: a randomized, placebo-controlled, double-blind pilot trial.
J Allergy Clin Immunol. 2005 Jan;115(1):125-31.

Retrospective Analysis - Rains, et al. (incl. Pump Spray Analysis)

Rains BM, Katz LM, Casciano R, Stern L, Britt G, Wiederkehr D, Stergiou
AM. Amphotericin B Nasal Spray in Chronic Sinusitis Chart Review.
American Academy of Otolaryngology-Head and Neck Surgery Foundation,
Toronto, Ontario, September 2006, Poster SP218. Poster Presentation.

Rains BM, Katz LM, Stern LS, Wiederkehr DP, Arikian SR. The Use of
Intranasal Amphotericin B in Chronic Rhinosinusitis Patients: A U.S.
Retrospective Chart Review. American College of Allergy, Asthma, and
Immunology 2005 Annual Meeting, Anaheim, California, November 4-9, 2005,
Poster #P104. Poster Presentation.

Immunologic Basis

Shin, et al. (a study of the enhanced immune response leading to CRS):
Chronic rhinosinusitis: an enhanced immune response to ubiquitous airborne fungi.
J Allergy Clin Immunol. 2004 Dec;114(6):1369-75.

Fungal Culture and Antigenic Markers

Braun, et al. ‘Eosinophilic Fungal Rhinosinusitis’: A Common Disorder in Europe? Laryngoscope 113: February 2003

Ponikau, et al.The Diagnosis and Incidence of Allergic Fungal Sinusitis Mayo Clin Proc, Volume 74(9).September 1999.877-884

Finding the Fungal Antigen

Inoue, Y, et al. Nonpathogenic, Environmental Fungi Induce Activation and
Degranulation of Human Eosinophils. Journal of Immunology, 2005, 175: 5439–5447.

Microbiology

Ponikau, et al. The Diagnosis and Incidence of Allergic Fungal Sinusitis. Mayo Clin. Proc 1999;74;877-884

Analyst Research Reports on Sinunase

Research report - August 2006 (Jeffries and Co)

Research report - August 2006 (Thomas Weissel Partners)

Powerpoint presentation on Sinunase - August 2006 (MS Powerpoint)