Revimmune Literature References and Clinical Trials

Review Articles:

Brodsky, R.A. High dose cyclophosphamide treatment for autoimmune
disorders. The Scientific World Journal 2:1808-1815, 2002

Brodsky, R.A. Biology and management of acquired severe aplastic
anemia. Current Opinion in Oncology 10:95-99, 1998.

Brodsky, R.A., Smith, B.D. Bone marrow transplantation for autoimmune
diseases. Current Opinion in Oncology 11: 83-86, 1999.

Brodsky, R.A. High-dose cyclophosphamide for aplastic anemia and
autoimmunity. Current Opinion in Oncology, 14:143-146, 2002.

Drachman, D.B., Brodsky, R.A. High dose therapy for autoimmune
neurologic disease. Current Opinion in Oncology, 17(2):83-8, 2005.

Research and Clinical Experimental Articles

Multiple Sclerosis

Gladstone DE, Zamkoff KW, High-Dose Cyclophosphamide for
Moderate to Severe Refractory Multiple Sclerosis, Arch Neurol. 2006 Aug 14

Krishnan, Drachman, et al.High-Dose Cyclophosphamide in the Treatment of Aggressive Multiple Sclerosis ( AAN Annual Meeting: 2006) Abstract

Multifocal Motor Neuropathy

Brannagan TH 3rd, Alaedini A, Gladstone DE. High-dose cyclophosphamide
without stem cell rescue for refractory multifocal motor neuropathy. Muscle Nerve. 2006 Aug;34(2):246-50.

Low Grade and Mantle Cell Lymphoma

ASH 2006 Poster Session: Phase II Study of High Dose Outpatient Cyclophosphamide and Rituximab, without Stem Cell Support, for Low Grade and Mantle Cell Lymphoma. Session Type: Poster Session, Board #919-II; Abstract 2741

Aplastic Anemia

ASH 2006 Poster Session: Savage, et al. Treatment of Hepatitis-Associated Aplastic Anemia with High Dose Cyclophosphamide. Session Type: Poster Session, Board #103-I ; Abstract 179

Brodsky, R.A., Sensenbrenner L.L., Jones, R.J. Complete remission in
severe aplastic anemia after high-dose cyclophosphamide without bone marrow
transplantation. Blood 87:491-494, 1996.

Brodsky, R.A., Sensenbrenner, L.L., Smith, B.D., Dorr, D., Seaman, P.J.,
Lee, S.M., Karp, J.E., Brodsky, I., Jones, R.J. Durable treatment-free remission
following high-dose cyclophosphamide for previously untreated severe aplastic
anemia. Annals of Internal Medicine, 135:477-483, 2001.

Brodsky, R.A., Chen, A., Brodsky, I., Jones, R.J. High Dose
Cyclophosphamide as Salvage Therapy for Severe Aplastic Anemia. Experimental
Hematology, 32:435-440, 2004.

Brodsky, R.A., Jones, R.J. Riddle: What do aplastic anemia, acute
promyelocytic leukemia, and chronic myeloid leukemia have in common? Leukemia,
18(10):1740-2, 2004.

Brodsky, R.A. Acquired Severe Aplastic Anemia in Children: Is there a
standard of care? Pediatric Blood and Cancer, 43(7):711-2, 2004.

Brodsky, R.A., Jones, R.J. Aplastic Anemia. Lancet, In press.

Veidt, R.G., Ansari-Lari, A., Brodsky, R.A. Severe Aplastic Anemia associated
with Paroxysmal Nocturnal Hemoglobinuria and Lymphoplasmacytic Lymphoma.
Leukemia and Lymphoma.

Autoimmune Hemolytic Anemia

Moyo, V.M., Smith, B.D., Brodsky, I., Crilley, P., Jones, R.J., Brodsky,
R.A. High-dose cyclophosphamide for refractrory autoimmune hemolytic anemia.
Blood, 100:704-706, 2002.

Systemic Lupus Erythematosus / Rheumatoid Arthritis / SA

Brodsky, R.A., Petri, M., Smith, B.D, Seifter, E.J., Spivak, J.L.,
Styler, M., Dang, C.V., Brodsky, I., Jones, R.J. Immunoablative high-dose
cyclophosphamide without stem cell rescue for refractory severe autoimmune
disease. Annals of Internal Medicine 129: 1031-1035, 1998.

Petri, M., Jones, R.J., Brodsky, R.A. High dose cyclophosphamide without
stem cell transplantation in systemic lupus erythematosus. Arthritis and
Rheumatism, 48:166-173, 2003.

Gladstone DE, Prestrud AA. High-dose cyclophosphamide for severe systemic lupus erythematosus.
Lupus. 2002;11(7):405-10.

Paraneoplastic Pemphigus / Pemphigus Vulgaris

Nousari, H.C., Brodsky, R.A., Jones, R.J., Grever, M.R., Anhalt, G.J.
Immunoablative high-dose cyclophosphamide without stem cell rescue in
paraneoplastic pemphigus: Report of a case and review of this new therapy for
severe autoimmune disease. Journal of the American Academy of Dermatology 40:
750-754, 1999.

Nousari CH, Brodsky R, Anhalt GJ. Evaluating the role of immunoablative
high-dose cyclophosphamide therapy in pemphigus vulgaris. Journal of the
American Academy of Dermatology, 49(1):148-50, 2003.

Transplantation

Brodsky, R.A., Fuller, A.K., Ratner, L.E., Leffell, M.S., Jones, R.J.
Elimination of alloantibodies by immunoablative high-dose cyclophosphamide.
Transplantation 71(3):482-484,2001

Myasthenia Gravis

Drachman, D.B., Jones, R.J., Brodsky, R.A. Treatment of refractory
myasthenia gravis: "rebooting" with high dose cyclophosphamide. Annals of
Neurology, 53:29-34, 2003.

D.E. Gladstone and T.H. Brannagan. High dose cyclophosphamide for severe refractory myasthenia gravis.
Journal of Neurology, Neurosurgery and Psychiatry 75.5 (May 2004): p789(2).

Lin PT, Martin BA, Weinacker AB, So YT. High-dose cyclophosphamide in refractory myasthenia gravis with MuSK antibodies.
Muscle Nerve. 2006 Mar;33(3):433-5.

Chronic Inflammatory Demyelinating Polyneuropathy (CIDP)

Gladstone DE, Prestrud AA, Brannagan TH 3rd.,
High-dose cyclophosphamide results in long-term disease remission with
restoration of a normal quality of life in patients with severe refractory
chronic inflammatory demyelinating polyneuropathy. J Peripher Nerv Syst. 2005 Mar;10(1):11-6.

Eliminating Transplant Rejection

Leo, et al. Post-Transplantation High-Dose Cyclophosphamide (Cy) Is Effective Single Agent GVHD Prophylaxis That Permits Prompt Immune Reconstitution after Myeloablative HLA Matched Related and Unrelated Bone Marrow Transplantation (BMT). Session Type: Poster Session, Board #120-III

Luznik, et al. Post-Transplantation high-dose cyclophosphamide is an effective single agent GVHD prophylaxis that permits prompt immune reconstitution after myeloablative HLA matched related and unrelated bone marrow transplantation (BMT)

Clinical Trials Relating to Revimmune

Gladstone: Stony Brooke Univ. Phase II High-Dose Cyclophosphamide for Multiple Sclerosis